Formin-mediated actin polymerization cooperates with Mud/Dynein during Frizzled/Dishevelled spindle orientation
نویسندگان
چکیده
Institute of Neuroscience, University of Oregon, Eugene, OR, 97403 Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR, 97403 Howard Hughes Medical Institute, University of Oregon, Eugene, OR, 97403 Present address: Department of Biology, University of New Mexico, Albuquerque, NM, 87131 Address for correspondence: Email: [email protected]; Email: [email protected] © 2013. Published by The Company of Biologists Ltd.
منابع مشابه
Formin-mediated actin polymerization cooperates with Mushroom body defect (Mud)-Dynein during Frizzled-Dishevelled spindle orientation.
To position the mitotic spindle, cytoskeletal components must be coordinated to generate cortical forces on astral microtubules. Although the dynein motor is common to many spindle orientation systems, 'accessory pathways' are often also required. In this work, we identified an accessory spindle orientation pathway in Drosophila that functions with Dynein during planar cell polarity, downstream...
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Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and constricting mitochondria. The force for constriction is thought to involve actin polymerization by the ER-anchored isoform of the formin protein inverted formin 2 (INF2). Unknown is the mechanism triggering INF2-mediated actin polymerization at ER-mitochondr...
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